Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Solubility of 5-FU determined in different types of oils and surfactants.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Solubility

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: 5-FU-DDTC complex formation by Keto-enol mechanism.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Distribution of 5-FU-NE is determined by dynamic light scattering techniques (A), zeta potential of 5-FU-NE (B), SEM images (C), and TEM images (D).

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Zeta Potential Analyzer

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: DSC-thermograms showed endothermic peaks of castor oil, 5-FU, Transcutol HP, PEG-400, 5-FU-NE, Carbopol and freeze dried optimized-5-FU-NE-Gel.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Spectral analysis of ATR of castor oil, 5-FU, Transcutol HP, PEG-400, 5-FU-NE, Carbopol and freeze dried optimized-5-FU-NE-Gel.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: showed the %age-cumulative-release of 5-FU from 5-FU-NE and 5-FU-NE-Gel when it compared with pure 5-FU-S.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: showed a comparative ex vivo various skins (cow, goat, & rat) permeation study of 5-FU from 5-FU-NE and 5-FU-NE-Gel.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Ex Vivo

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: %Age permeation of 5-FU and their retention of skin in stratum corneum (SC) and viable part of the skin ex-vivo from 5-FU, 5-FU-NE, and 5-FU-NE-Gel nanoformulation.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Ex Vivo

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Mass spectrum of 5-FU-MS-Scan i.e. protonated precursor [M-H] – ions at m / z 129 [A], 5-FU-MSMS-Scan fragmentation transitions i.e. major fragmented product ion at m / z 42 [B], and a chromatogram of UHPLC showing retention time 1.710 min.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Mass spectrum of Diethyldithiocarbamate (DDTC)-MS-Scan and Sodium-Diethyldithiocarbamate (DDTC)-MS-Scan showed at protonated precursor [M-H] – ions at m / z 147.27, and 170.21 [A], MS-Scan of complex 5-FU with Diethyldithiocarbamate (DDTC)-MS-Scan and Sodium-Diethyldithiocarbamate (DDTC)-MS-Scan product ion at m / z 277.09 and 300.26 [B], and a UHPLC chromatogram of showing retention time 0.736 and 2.185 min for DDTC chelating agent individual and DDTC–5-FU complex [C].

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Fluorescence micrographs of cow- and goat-ear pinna skin and rat skin treated with the formulation 5-FU-S (A) 5-FU-NE (B) 5-FU-NE-Gel (C). Different type of formulations labelled with hydrophilic fluorescence probe (6-carboxyfluorescein) to mark the penetration of the 5-FU to deep skin strata.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Fluorescence, Formulation

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: %Age-Cell viability (n = 3, SD, mean) of 5-FU in free 5-FU aqueous solution, control, and optimized-5-FU-NE, and 5-FU-NE-Gel nanoformulation on melanoma cell lines. Optimized–5-FU-NE3 (p < 0.05) and 5-FU-NE3-Gel (p < 0.01) were highly significant than free 5-FU-S.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: IC50 and % Cytotoxicity of free 5-FU, opt-5-FU-NE, 5-FU-NE-Gel, and control on melanoma cancer cell lines (n = 3).

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Concentration Assay

Journal: Dose-Response

Article Title: Biochemical Investigation of Inhibitory Activities of Plant-Derived Bioactive Compounds Against Carbohydrate and Glucagon-Like Peptide-1 Metabolizing Enzymes

doi: 10.1177/15593258221093275

Figure Lengend Snippet: Chemical structures of selected ligands for molecular docking analysis. (A) Chemical structures of tested compounds taxifolin (TAX) and resveratrol (RSV). (B) 2D-structural representation of standard compounds acarbose (ACB), miglitol (MGL), and diprotin (DPT). (C) Supposed conformation of selected hits and standard compound in their corresponding molecular targets.

Article Snippet: Resveratrol (CHEM-IMPEX INT’L INC), taxifolin (Sigma aldrich), acarbose (Carbosnyth,USA), diprotin (Sigma aldrich), HPA assay kit (Product code: K-CERA, Megazyme brand), α-glucosidase assay kit (Product code: MAK123, Sigma aldrich), DPP-IV inhibitor screening assay kit (Product code: ab133081 Abcam), starch (Sigma aldrich) and all the other materials of analytical grade were used.

Techniques:

Journal: Dose-Response

Article Title: Biochemical Investigation of Inhibitory Activities of Plant-Derived Bioactive Compounds Against Carbohydrate and Glucagon-Like Peptide-1 Metabolizing Enzymes

doi: 10.1177/15593258221093275

Figure Lengend Snippet: Inhibitory Activity of Bioactive Compounds Against GLU, HPA, and DPP-IV Enzymes.

Article Snippet: Resveratrol (CHEM-IMPEX INT’L INC), taxifolin (Sigma aldrich), acarbose (Carbosnyth,USA), diprotin (Sigma aldrich), HPA assay kit (Product code: K-CERA, Megazyme brand), α-glucosidase assay kit (Product code: MAK123, Sigma aldrich), DPP-IV inhibitor screening assay kit (Product code: ab133081 Abcam), starch (Sigma aldrich) and all the other materials of analytical grade were used.

Techniques: Activity Assay, Positive Control

Journal: Dose-Response

Article Title: Biochemical Investigation of Inhibitory Activities of Plant-Derived Bioactive Compounds Against Carbohydrate and Glucagon-Like Peptide-1 Metabolizing Enzymes

doi: 10.1177/15593258221093275

Figure Lengend Snippet: Surflex Score of Docked Ligands; Taxifolin and Resveratrol for GLU, HPA, and DPP-IV Along With Their Corresponding Standard Molecules Acarbose, Miglitol, and Diprotin A.

Article Snippet: Resveratrol (CHEM-IMPEX INT’L INC), taxifolin (Sigma aldrich), acarbose (Carbosnyth,USA), diprotin (Sigma aldrich), HPA assay kit (Product code: K-CERA, Megazyme brand), α-glucosidase assay kit (Product code: MAK123, Sigma aldrich), DPP-IV inhibitor screening assay kit (Product code: ab133081 Abcam), starch (Sigma aldrich) and all the other materials of analytical grade were used.

Techniques:

Journal: Diagnostics

Article Title: Preanalytical, Analytical and Postanalytical Analyses on Corynebacterium spp. and Actinomycetaceae in Urine Samples of Patients with Suspected Urinary Tract Infection—A Hypothesis-Forming Observational Study

doi: 10.3390/diagnostics14070746

Figure Lengend Snippet: Matches and mismatches between the applied analytic approaches.

Article Snippet: The obtained spectra were analyzed using the database Saramis version 15.10.13–18.11.14 (bioMerieux, Nürtingen, Germany) and the database Myla version 15.09.–24.11.2014 (bioMerieux, Nürtingen, Germany).

Techniques: Sequencing, Bacteria